LearningActivities ColorBlindness
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* 100 men are selected at random. What is the distribution of <math>X_m</math> = the number of these men that are colorblind? | * 100 men are selected at random. What is the distribution of <math>X_m</math> = the number of these men that are colorblind? | ||
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{{hidden| See the Answer| <math>X_m</math>~<math>Binomial(100,p)</math> }} | {{hidden| See the Answer| <math>X_m</math>~<math>Binomial(100,p)</math> }} | ||
* 100 women are selected at random. What is the distribution of <math>X_f</math> = the number of these women that are colorblind? | * 100 women are selected at random. What is the distribution of <math>X_f</math> = the number of these women that are colorblind? | ||
- | + | {{hidden| See a Hint| the chance that an individual woman is colorblind is <math>p^2</math>, why? }} | |
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+ | {{hidden| See the Answer| <math>X_f</math>~<math>Binomial(100,p^2) }} | ||
* To estimate the probability that a randomly selected woman is colorblind, you might use the proportion of colorblind women in a sample of n women. What is the variance of this estimator? | * To estimate the probability that a randomly selected woman is colorblind, you might use the proportion of colorblind women in a sample of n women. What is the variance of this estimator? | ||
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+ | {{hidden| See the Answer| <math>X_f</math>~<math>Binomial(n,p^2)</math>. Thus <math>Var(\frac{X_f}{n})=\frac{p^2(1-p^2)}{n}</math> }} | ||
* Alternatively, to estimate the probability that a randomly selected woman is colorblind, you might use the square of the proportion of colorblind men in a sample of n men. Explain why this estimate makes sense. What is the variance of this estimator? | * Alternatively, to estimate the probability that a randomly selected woman is colorblind, you might use the square of the proportion of colorblind men in a sample of n men. Explain why this estimate makes sense. What is the variance of this estimator? | ||
- | + | {{hidden| See a Hint| The moment generating function can be used to find the fourth moment about the origin. }} | |
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+ | {{hidden| See the Answer| We want to estimate <math>p^2</math> and <math>\frac{X_m}{n}</math> estimates <math>p</math> so it makes sense to use <math>(\frac{X_m}{n})^2</math> as the estimator (in fact it will be the [http://wiki.stat.ucla.edu/socr/index.php/AP_Statistics_Curriculum_2007_Estim_MOM_MLE#Maximum_Likelihood_Estimation_.28MLE.29 maximum likelihood estimate]). We have <math>Var[( \frac{X_m}{n} )^2 ] = n^{-4}[E(X_m^4 ) - (E(X_m^2 ))^2 ]</math>. Take <math>q=1-p</math>. Then the fourth moment about the origin of a binomial is <math>E(X^4)= np(q-6pq^2+7npq-11np^2q+6n^2p^2q+n^3p^3)</math> and the second moment is <math>E(X^2)=np(q+np)</math>. Thus <math>Var[( \frac{X_m}{n} )^2 ] = n^{-3}(pq + 6(n-1)p^2q^2 + 4n(n-1)p^3q)</math>. }} | ||
# For large samples, is it better to use a sample of men or a sample of women to estimate the probability that a randomly selected women is colorblind? Explain. | # For large samples, is it better to use a sample of men or a sample of women to estimate the probability that a randomly selected women is colorblind? Explain. | ||
- | + | {{hidden| See a Hint| Show that a normal approximation is valid for both and then compare the variances.} | |
- | + | {{hidden| See the Answer| For large n the ratio of the variances for the estimate in part c to the estimate in part d is <math>\frac{Var(\frac{X_f}{n})}{Var((\frac{X_m}{n})^2 )} \sim \frac{p^2(1-p^2)}{4p^3q} = \frac{1+ p}{4p}</math>. When this ratio is greater than 1, the estimator based on the sample of men will be better. Since this happens for any <math>p < \frac{1}{3}</math>, which is clearly the case for colorblindness, it is better to use a sample of men to estimate the probability that a random woman is colorblind.}} | |
===Conclusions=== | ===Conclusions=== |
Revision as of 20:06, 25 October 2011
Contents |
Distributome Learning Activities - Distributome Colorblindness Activity
Overview
This Distributome Activity illustrates an application of probability theory to study Colorblindness.
Colorblindness results from an abnormality on the X chromosome. The condition is thus rarer in women since a woman would need to have the abnormality on both of her X chromosomes in order to be colorblind (whether a woman has the abnormality on one X chromosome is essentially independent of having it on the other).
Goals
The goal of this activity is to demonstrate an efficient protocol of estimating the probability that a randomly chosen individual may be colorblind.
Hands-on Activity
Suppose that p is the probability that a randomly selected man is colorblind.
- 100 men are selected at random. What is the distribution of Xm = the number of these men that are colorblind?
- 100 women are selected at random. What is the distribution of Xf = the number of these women that are colorblind?
- Alternatively, to estimate the probability that a randomly selected woman is colorblind, you might use the square of the proportion of colorblind men in a sample of n men. Explain why this estimate makes sense. What is the variance of this estimator?
- For large samples, is it better to use a sample of men or a sample of women to estimate the probability that a randomly selected women is colorblind? Explain.
{{hidden| See a Hint| Show that a normal approximation is valid for both and then compare the variances.}
Conclusions
You can also use the delta method to find the approximate variance for the estimator above.
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