SOCR Events FTO Obesity Neuroimaging2010

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SOCR News - Neuroimaging study of obesity and brain tissue loss using the SOCR computational libraries

SOCR volumetric Regression coefficient (unstandardized beta) maps for regional brain volume correlating with FTO, after adjusting for age and sex (Upper) compared to unthresholded regression coefficient maps for regional brain volume correlating with FTO, after adjusting for age, sex, and BMI (Lower). Unthresholded maps are shown (Lower) as there were no significant regions after correcting at 5% SOCR FDR in the whole brain analysis after adjusting for age, sex, and BMI. This is perhaps to be expected as FTO influences BMI. Images are displayed in radiological convention (left side of the brain shown on the right) and are displayed over a study-specific brain image template (MDT).

PNAS published the largest neuroimaging study to-date identifying the relations between obesity gene (FTO) and brain tissue loss using the SOCR computational libraries.

Reporting in the journal Proceedings of the National Academy of Sciences, UCLA investigators found that the FTO obesity gene is associated with a loss of brain tissue. This puts more than a third of the U.S. population at risk for a variety of diseases, such as Alzheimer's. This study used the SOCR computational libraries and SOCR Analyses to identify multivariate relations between subject demographic and imaging data.

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